CHROMOSOMAL DAMAGES BY ETHANOL AND ACETALDEHYDE IN SACCHAROMYCES-CEREVISIAE AS STUDIED BY PULSED-FIELD GEL-ELECTROPHORESIS

Authors
RISTOW H SEYFARTH A LOCHMANN ER
Citation
H. Ristow et al., CHROMOSOMAL DAMAGES BY ETHANOL AND ACETALDEHYDE IN SACCHAROMYCES-CEREVISIAE AS STUDIED BY PULSED-FIELD GEL-ELECTROPHORESIS, Mutation research, 326(2), 1995, pp. 165-170
Citations number
17
Categorie Soggetti
Genetics & Heredity",Biology,"Biothechnology & Applied Migrobiology
Journal title
Mutation research → ACNP
ISSN journal
00275107
Volume
326
Issue
2
Year of publication
1995
Pages
165 - 170
Database
ISI
SICI code
0027-5107(1995)326:2<165:CDBEAA>2.0.ZU;2-I
Abstract
We report on the effect of ethanol and acetaldehyde on yeast chromosom al DNA and on isolated DNA. Ethanol induced DNA single-strand breaks i n repair deficient but not in repair proficient Saccharomyces cerevisi ae. Acetaldehyde has a deleterious effect on chromosomal DNA in cells as well as on isolated DNA. The results presented support earlier data to show that ethanol is mutagenic via its first metabolite, acetaldeh yde.