ENHANCEMENT OF CYTOGENETIC DAMAGE AND OF ANTINEOPLASTIC EFFECT IN LYMPHOID L1210 LEUKEMIA-CELLS TREATED WITH PROSTAGLANDIN-E2 AND CYCLOPHOSPHAMIDE IN-VIVO

An enhanced frequency of sister-chromatid exchanges (SCEs) and increas ed cell division delays induced by cyclophosphamide (CP) were observed when lymphoid L1210 leukemia cells were post-treated in vivo with pro staglandin E2 (PGE2). CP gave a slight, non-significant increase in su rvival while PGE2 gave a slight, non-significant decrease in survival. However, PGE2 in combination with CP was found to have a non-signific ant potentiating effect on survival in comparison with mice treated wi th CP alone. In mice treated with the combined CP (5 mu g/g b.w.) plus PGE2 (2 mu g/g b.w.) treatment, a significant (P < 0.01) enhancement of survival time in comparison with the untreated controls was observe d.