S. Ranganathan et al., THE CRAFTING OF URACILS WITH ENHANCED STACKING POTENTIAL, Proceedings of the Indian Academy of Sciences. Chemical sciences, 106(5), 1994, pp. 1051-1070
Uracils having enhanced stacking profile are of interest from diverse
vantages ranging from the chemical simulation of transcription to the
design of novel anti viral agents. This objective has been realized by
synthetic strategies leading to uracils having, inter alia, pseudo ar
omatic and hydrophobic rings crafted to the 5-6 location and ionophore
and hydrophobic chains affixed at the C-5 and nitrogen atoms. Endeavo
urs to prepare a 5-2' uracil-pyrimidine composite have led to novel ur
acil arising from 2-0 --> =CH(COOR)(2) transformation and a tethered m
alonic acid pyrimidine complex.