THE CRAFTING OF URACILS WITH ENHANCED STACKING POTENTIAL

Uracils having enhanced stacking profile are of interest from diverse vantages ranging from the chemical simulation of transcription to the design of novel anti viral agents. This objective has been realized by synthetic strategies leading to uracils having, inter alia, pseudo ar omatic and hydrophobic rings crafted to the 5-6 location and ionophore and hydrophobic chains affixed at the C-5 and nitrogen atoms. Endeavo urs to prepare a 5-2' uracil-pyrimidine composite have led to novel ur acil arising from 2-0 --> =CH(COOR)(2) transformation and a tethered m alonic acid pyrimidine complex.