D. Dauzonne et al., SYNTHESIS AND SOME CNS ACTIVITIES OF NEW BENZOFURANYLACRYLOYLPIPERAZINES, European journal of medicinal chemistry, 30(1), 1995, pp. 53-59
A series of novel benzofuranylacryloylpiperazines, which are structura
lly related to both cinnamamide derivatives and befuraline, have been
prepared as their hydrochlorides. Their anticonvulsant and antidepress
ant activities against seizures induced by electroshock and against te
trabenazine-induced palpebral ptosis have been evaluated in mice. Some
of them revealed interesting potencies since, although they are less
active than the reference drugs, they exhibited a higher protective in
dex.