A RETROSPECTIVE COMPARATIVE-STUDY EVALUATING THE RESULTS OF MILD HYPERTHERMIC VERSUS CONTROLLED NORMOTHERMIC PERFUSION FOR RECURRENT MELANOMA OF THE EXTREMITIES

The aim of this study was to investigate the role of mild hyperthermia (39-40 degrees C) in isolated cytostatic perfusion for patients with recurrent melanoma of the extremities. A total of 218 patients treated with mild hyperthermic perfusion was compared to 166 patients perfuse d under controlled normothermic conditions (37-38 degrees C). Only pat ients whose lesions had been excised before or at the moment of perfus ion were eligible for this study. A variety of prognostic factors was controlled for in a Cox proportional hazards analysis. The application of mild hyperthermia did not influence limb recurrence-free interval nor survival (corrected P values 0.46 and 0.18, respectively). In this retrospective comparative study, no benefit for mild hyperthermia in regional isolated perfusion could be identified.