We studied sympathetic fibres in the cavernous sinus in 40 unfixed spe
cimens obtained from human cadavers. Sympathetic fibres in the caverno
us sinus are understood to be grouped in a plexiform configuration sur
rounding the internal carotid artery and have a diffuse distribution a
mong the sympathetic nerves. Our study, however, suggests that a more
systematic arrangement of sympathetic pathways exists in the cavernous
sinus. A detailed anatomical description of intracavernous sympatheti
c fibres contributes to academic anatomical knowledge and may have pra
ctical applications for 1. diagnostic interpretation of pathologic con
ditions involving the cavernous sinus, 2. recognition and orientation
oi anatomical structures during intracavernous surgical procedures, an
d 3. a deeper understanding of the sympathetic nerve supply to cerebra
l vasculature.