ACIDIC AND BASIC FIBROBLAST GROWTH-FACTORS ENHANCE NEURITE OUTGROWTH IN CULTURED RAT SPINAL-CORD NEURONS

Authors
IWASAKI Y SHIOJIMA T IKEDA K TAGAYA N KOBAYASHI T KINOSHITA M
Citation
Y. Iwasaki et al., ACIDIC AND BASIC FIBROBLAST GROWTH-FACTORS ENHANCE NEURITE OUTGROWTH IN CULTURED RAT SPINAL-CORD NEURONS, Neurological research, 17(1), 1995, pp. 70-72
Citations number
22
Categorie Soggetti
Neurosciences
Journal title
Neurological research → ACNP
ISSN journal
01616412
Volume
17
Issue
1
Year of publication
1995
Pages
70 - 72
Database
ISI
SICI code
0161-6412(1995)17:1<70:AABFGE>2.0.ZU;2-X
Abstract
We have studied neurotrophic effects of acidic fibroblast growth facto r (aFCF) and basic fibroblast growth factor (bFGF) on explanted ventra l and dorsal spinal cord cultures from 13- and 14-day-old rat embryos. Cultures treated with aFCF and bFCF significantly enhanced neurite ou tgrowth with cultures of ventral spinal card, but not with cultures of dorsal spinal cord. Our data suggest that aFGF and bFGF are potent ne urotrophic factors on rat ventral spinal cord neurons in vitro.