THE BISINDOLYLMALEIMIDE GF 109203X, A SELECTIVE INHIBITOR OF PROTEIN-KINASE-C, DOES NOT INHIBIT THE POTENTIATING EFFECT OF PHORBOL ESTER ONETHANOL-INDUCED PHOSPHOLIPASE C-MEDIATED HYDROLYSIS OF PHOPHATIDYLETHANOLAMINE

In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myrist ate (PMA) either inhibits or stimulates phospholipase C-mediated hydro lysis of phosphatidylethanolamine in the absence or presence of ethano l, respectively. Here, we demonstrate that the specific PKC inhibitor bisindolylmaleimide GF 109203X prevents only the inhibitory, but not t he stimulatory, PMA effect.