SIMPLE RAPID HYDROLYSIS OF ACETYL PROTECTING GROUPS IN THE FDG SYNTHESIS USING CATION-EXCHANGE RESINS

Authors
MULHOLLAND GK
Citation
Gk. Mulholland, SIMPLE RAPID HYDROLYSIS OF ACETYL PROTECTING GROUPS IN THE FDG SYNTHESIS USING CATION-EXCHANGE RESINS, Nuclear medicine and biology, 22(1), 1995, pp. 19-23
Citations number
11
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging
Journal title
Nuclear medicine and biology
ISSN journal
09698051 → ACNP
Volume
22
Issue
1
Year of publication
1995
Pages
19 - 23
Database
ISI
SICI code
0969-8051(1995)22:1<19:SRHOAP>2.0.ZU;2-V
Abstract
A new solid phase method for hydrolysis of acetyl groups from the inte rmediate 2-[F-18]fluoro-2-deoxyglucose tetraacetate ([F-18]FDG-Ac-4) w as developed. Fast cleavage occurs with Dowex 50 sulfonic acid resin ( H+ form) at similar to lOO degrees C in the absence of bulk water. [F- 18]FDG-Ac-4 reaction mixtures were efficiently converted to neutral aq ueous solutions of pure FDG in 10-15 min. The method avoids problems a ssociated with liquid acids and can be easily integrated into existing [F-18]FDG procedures.