Gk. Mulholland, SIMPLE RAPID HYDROLYSIS OF ACETYL PROTECTING GROUPS IN THE FDG SYNTHESIS USING CATION-EXCHANGE RESINS, Nuclear medicine and biology, 22(1), 1995, pp. 19-23
A new solid phase method for hydrolysis of acetyl groups from the inte
rmediate 2-[F-18]fluoro-2-deoxyglucose tetraacetate ([F-18]FDG-Ac-4) w
as developed. Fast cleavage occurs with Dowex 50 sulfonic acid resin (
H+ form) at similar to lOO degrees C in the absence of bulk water. [F-
18]FDG-Ac-4 reaction mixtures were efficiently converted to neutral aq
ueous solutions of pure FDG in 10-15 min. The method avoids problems a
ssociated with liquid acids and can be easily integrated into existing
[F-18]FDG procedures.