STRUCTURE AND RELATIVE STEREOCHEMISTRY OF A NEW POLYCYCLIC ALKALOID, ASPARAGAMINE-A, SHOWING ANTI-OXYTOCIN ACTIVITY, ISOLATED FROM ASPARAGUS-RACEMOSUS

Authors
SEKINE T IKEGAMI F FUKASAWA N KASHIWAGI Y AIZAWA T FUJII Y RUANGRUNGSI N MURAKOSHI I
Citation
T. Sekine et al., STRUCTURE AND RELATIVE STEREOCHEMISTRY OF A NEW POLYCYCLIC ALKALOID, ASPARAGAMINE-A, SHOWING ANTI-OXYTOCIN ACTIVITY, ISOLATED FROM ASPARAGUS-RACEMOSUS, Journal of the Chemical Society. Perkin transactions. I, (4), 1995, pp. 391-393
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
4
Year of publication
1995
Pages
391 - 393
Database
ISI
SICI code
0300-922X(1995):4<391:SARSOA>2.0.ZU;2-B
Abstract
The relative stereochemistry of a new cage-type alkaloid, asparagamine A 1. isolated from the roots of Asparagus racemosus Willd. (Liliaceae ). has been elucidated by spectroscopic, chemical and single-crystal X -ray analyses. This novel polycyclic pyrrolizidine derivative is both the first alkaloid to be isolated from this genus and also the first p yrrolizidine derivative with carbon substituents at C-5 and C-8. The c ompound showed anti-oxytocin activity in vitro in a dose of 10(-5)-10( -6) mg cm(-3).