CARCINOSARCOMA OF THE SKIN - CASE-REPORT AND LITERATURE-REVIEW

A case of carcinosarcoma arising in the skin of the left arm of a 69-y ear-old woman is reported with a review of the literature. The tumor w as composed of low-differentiated squamous cell carcinoma, which was i ntermingled with a pleomorphic sarcoma. The carcinomatous component ha d keratin and lacked vimentin. whereas the phenotype of the sarcomatou s portion was the reverse. The former presented additionally focal exp ression of S-100 protein, which was lacking in other portions of the c arcinoma. The phenotypic data, supplemented by p53 immunostaining, whi ch was present in both components, suggest their common origin in this tumor.