EFFICACY OF NEW ORGANIC AMMONIUM-SALTS ON PSEUDOMONAS-AERUGINOSA AND SALMONELLA-TYPHIMURIUM

The inhibitory activities of four new homologous series of organic amm onium salts (OAS) were tested on bacterial strains isolated from patie nts. Two types of compounds were used ''hard'' (group A) and three gro ups (B, C, D) of biodegradable ''soft'' OAS with metabolically labile CO or NH groups in their molecules. The strain Pseudomonas aeruginosa was isolated from the sputum of a patient with carcinoma. The strain S almonella typhimurium was isolated from a patient with clinical diagno sis of diarrhea. In all homologous series, the antibacterial activity was increasing continuously, with the length of alkyl chain lip to dod ecyl or tetradecyl, then the ''cut off' effect vas observed. The most active compounds from both ''hard'' and ''soft'' types had superior ac tivity to commercial disinfectants The strain of Pseudomonas aeruginos a was more sensitive to these compounds than that of Salmonella typhim urium.