COMPARISON OF IOPAMIDOL AND IOVERSOL IN-VITRO AND IN ANIMAL STUDIES

In the present sei ies of studies we investigated differences in vitro and in animal experiments between iopamidol (Iopamiron(R), CAS 60166- 93-0) and ioversol (CAS 87771-40-2). The studies included the in vitro investigations partition coefficient, lysozyme inhibition, coagulatio n time and erythrocyte morphology as well as the in vivo paradigms acu te toxicity, neural toxicity, general behavior/locomotor activity and angiography. Iopamidol was superior to ioversol in most of the tests. in spite of its higher hydrophilicity, ioversol did not show improved tolerance in comparison to iopamidol.