DECREASED ORAL BIOAVAILABILITY OF LANSOPRAZOLE IN HEALTHY-VOLUNTEERS WHEN GIVEN WITH A STANDARDIZED BREAKFAST

Authors
BERGSTRAND R GRIND M NYBERG G OLOFSSON B
Citation
R. Bergstrand et al., DECREASED ORAL BIOAVAILABILITY OF LANSOPRAZOLE IN HEALTHY-VOLUNTEERS WHEN GIVEN WITH A STANDARDIZED BREAKFAST, Clinical drug investigation, 9(2), 1995, pp. 67-71
Citations number
6
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Clinical drug investigation → ACNP
ISSN journal
11732563
Volume
9
Issue
2
Year of publication
1995
Pages
67 - 71
Database
ISI
SICI code
1173-2563(1995)9:2<67:DOBOLI>2.0.ZU;2-Q
Abstract
12 healthy male volunteers participated in this open, randomised, cros sover study. On 2 study days at least 6 days apart the volunteers were given a single oral dose of lansoprazole 30mg with or without a stand ardised breakfast. When lansoprazole was concomitantly given with brea kfast, the peak plasma concentration (C-max) and area under the concen tration-time curve (AUG) were decreased by approximately 50% for each of the two parameters. The time to reach C-max (t(max)) was doubled wh en lansoprazole was coadministered with breakfast. In conclusion, lans oprazole should not be taken concomitantly with food.