LACK OF INFLUENCE OF PANTOPRAZOLE ON CARDIOVASCULAR FUNCTION IN HEALTHY-VOLUNTEERS - A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED CROSSOVER STUDY

Eight healthy volunteers received a 6-minute infusion of pantoprazole 80mg and placebo in a double-blind randomised crossover study. Cardiov ascular function was investigated at rest and during exercise by measu ring blood pressure, heart rate and EGG, and also during passive postu ral stress on a tilt table. Cardiac performance was assessed noninvasi vely by means of systolic time intervals (STIs). Serum concentrations of pantoprazole were measured by high-performance liquid chromatograph y. Following the 6-minute infusion, no clinically relevant changes in blood pressure, heart rate, EGG, STI or routine laboratory parameters were observed after placebo or pantoprazole. Both infusions were well tolerated. A minor influence of pantoprazole on orthostatic regulation of diastolic blood pressure could not be excluded during the tilt tab le test, but, if present, was judged to be of no clinical importance. It was concluded from the systolic time intervals that pantoprazole ha d no influence on cardiac contractility.