ENANTIOMERIC EXCESS ANALYSIS OF (2R, 3S)-3-DEUTERIO-2-METHYLCYCLOHEXANONE AND (1S, 2R, 3S)-3-DEUTERIO-2-METHYLCYCLOHEXANOL, THROUGH DEUTERIUM NMR IN A POLYPEPTIDE LYOTROPIC LIQUID-CRYSTAL

Authors
CANET I COURTIEU J DAUPHIN G GOURCY JG VESCHAMBRE H
Citation
I. Canet et al., ENANTIOMERIC EXCESS ANALYSIS OF (2R, 3S)-3-DEUTERIO-2-METHYLCYCLOHEXANONE AND (1S, 2R, 3S)-3-DEUTERIO-2-METHYLCYCLOHEXANOL, THROUGH DEUTERIUM NMR IN A POLYPEPTIDE LYOTROPIC LIQUID-CRYSTAL, Tetrahedron : asymmetry, 6(2), 1995, pp. 333-336
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
6
Issue
2
Year of publication
1995
Pages
333 - 336
Database
ISI
SICI code
0957-4166(1995)6:2<333:EEAO(3>2.0.ZU;2-E
Abstract
Poly-gamma-benzyl-L-glutamate (PBLG) and dichloromethane form a lyotro pic liquid crystal which can be used as solvent for enantiomeric exces s analysis of molecules containing several stereogenic centers, throug h deuterium NMR spectroscopy. All isomers of 3-deuterio-2-methylcycloh exanone and of 3-deuterio-2-methylcyclohexanol dissolved in PBLG/CH(2) Cl2 solvents, exhibit different quadrupolar splittings on their deuter ium NMR spectra, which allows an accurate determination of their diast ereoisomeric and enantiomeric excesses.