ASYMMETRIC-SYNTHESIS OF TRANS-2,5-DIPHENYLPYRROLIDINE - A C-2-SYMMETRICAL CHIRAL AMINE

Authors
CHONG JM CLARKE IS KOCH I OLBACH PC TAYLOR NJ
Citation
Jm. Chong et al., ASYMMETRIC-SYNTHESIS OF TRANS-2,5-DIPHENYLPYRROLIDINE - A C-2-SYMMETRICAL CHIRAL AMINE, Tetrahedron : asymmetry, 6(2), 1995, pp. 409-418
Citations number
76
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
6
Issue
2
Year of publication
1995
Pages
409 - 418
Database
ISI
SICI code
0957-4166(1995)6:2<409:AOT-AC>2.0.ZU;2-8
Abstract
(R,R)-2,5-Diphenylpyrrolidine of high enantiomeric purity (>98% e.e.) may be prepared from 1,4-diphenyl-1,4-butanedione in 4 steps and 64% o verall yield. A key step is asymmetric reduction of the dione with Ipc (2)BCl.