K. Nagren et al., IMPROVED SYNTHESIS OF SOME COMMONLY USED PET RADIOLIGANDS BY THE USE OF [C-11] METHYL TRIFLATE, Nuclear medicine and biology, 22(2), 1995, pp. 235-239
[C-11]Methyl triflate was compared with [C-11]methyl iodide as a label
led precursor in the synthesis of some commonly used PET radioligands,
L-[C-11]deprenyl, [C-11]m-hydroxyephedrine (MHED), [C-11]beta-CIT, [C
-11]beta-CFT and [C-11]SCH 39166 which have been prepared previously i
n comparatively low yields from C-11]methyl iodide. A new dopamine reu
ptake radioligand, [C-11]alpha-CIT, was also prepared. The results dem
onstrate that higher yields are obtained with shorter reaction times,
lower reaction temperatures and smaller amounts of precursors with [C-
11]methyl triflate.