SYNTHESIS OF WATER-SOLUBLE SUGAR-DERIVATIVES OF COMBRETASTATIN A-4

Authors
BROWN RT FOX BW HADFIELD JA MCGOWN AT MAYALARP SP PETTIT GR WOODS JA
Citation
Rt. Brown et al., SYNTHESIS OF WATER-SOLUBLE SUGAR-DERIVATIVES OF COMBRETASTATIN A-4, Journal of the Chemical Society. Perkin transactions. I, (5), 1995, pp. 577-581
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
5
Year of publication
1995
Pages
577 - 581
Database
ISI
SICI code
0300-922X(1995):5<577:SOWSOC>2.0.ZU;2-T
Abstract
Three sugar derivatives (6, 7 and 13) of the antimitotic agent combret astatin A-4 1 have been synthesized. Two of these water-soluble deriva tives (6, 13) showed strong cytotoxicity to the murine P388 cell line.