A LOCAL RENIN-ANGIOTENSIN-LIKE SYSTEM IN THE HEART OF AN AFRICAN LUNGFISH (PROTOPTERUS ANNECTENS)

Authors
MASINI MA DEVECCHI M NAPOLI L UVA BM
Citation
Ma. Masini et al., A LOCAL RENIN-ANGIOTENSIN-LIKE SYSTEM IN THE HEART OF AN AFRICAN LUNGFISH (PROTOPTERUS ANNECTENS), Comparative biochemistry and physiology. Part A, Physiology, 110(3), 1995, pp. 229-233
Citations number
24
Categorie Soggetti
Physiology,Biology
Journal title
Comparative biochemistry and physiology. Part A, Physiology → ACNP
ISSN journal
10964940
Volume
110
Issue
3
Year of publication
1995
Pages
229 - 233
Database
ISI
SICI code
1096-4940(1995)110:3<229:ALRSIT>2.0.ZU;2-F
Abstract
The presence of components of a renin-angiotensin system was investiga ted in the heart of an African lungfish Protopterus annectens. A renin -like activity is present in heart homogenates. The activity reaches i ts maximum after 90 min of incubation at 20 degrees C. By a spectropho tometric assay, an angiotensin converting enzyme-like activity was det ected. By immunohistochemistry Ile(5)-Angiotensin II immunoreactive ca rdiocytes were demonstrated in the atrium and bulbus. Our data indicat e that probably a local renin-angiotensin-like system is present in th e heart of Protopterus annectens.