THE LIVER AND MUSCLE OF EARLY UPSTREAM MIGRANT LAMPREYS (GEOTRIA-AUSTRALIS) CONTAIN HIGH-LEVELS OF ACETYL-COA CARBOXYLASE AND A CARNITINE PALMITOYL TRANSFERASE-I THAT IS SENSITIVE TO MALONYL-COA
Mh. Cake et al., THE LIVER AND MUSCLE OF EARLY UPSTREAM MIGRANT LAMPREYS (GEOTRIA-AUSTRALIS) CONTAIN HIGH-LEVELS OF ACETYL-COA CARBOXYLASE AND A CARNITINE PALMITOYL TRANSFERASE-I THAT IS SENSITIVE TO MALONYL-COA, Comparative biochemistry and physiology. B. Comparative biochemistry, 110(2), 1995, pp. 417-423
The exceptionally high lipid levels in the muscle and liver of Geotria
australis, at the completion of the marine trophic phase, are both ac
companied by a very high activity of acetyl-CoA carboxylase (ACC). ACC
activity declines markedly during the subsequent protracted, nontroph
ic spawning run, The above and other data suggest that, in lampreys, t
he muscle tissue, as well as the liver, is lipogenic. Carnitine palmit
oyl transferase I of lamprey muscle is extremely sensitive to malonyl-
CoA, a feature which would enable fatty acid oxidation to be inhibited
during any period of lipogenesis in this tissue.