COMPARATIVE-EVALUATION OF THE INFLUENCE OF PROPOFOL AND THIOPENTAL ONTHE ONSET TIME, DURATION OF ACTION AND RECOVERY OF PIPECURONIUM

Citation
V. Vilardi et al., COMPARATIVE-EVALUATION OF THE INFLUENCE OF PROPOFOL AND THIOPENTAL ONTHE ONSET TIME, DURATION OF ACTION AND RECOVERY OF PIPECURONIUM, Clinical drug investigation, 9(3), 1995, pp. 156-160
Citations number
26
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
ISSN journal
11732563
Volume
9
Issue
3
Year of publication
1995
Pages
156 - 160
Database
ISI
SICI code
1173-2563(1995)9:3<156:COTIOP>2.0.ZU;2-X
Abstract
Two groups of 15 patients each, with American Society of Anesthetists' (ASA) physical status I or II, were administered two single bolus dos es of propofol 2 mg/kg or thiopental 4 mg/kg, followed by pipecuronium 0.08 mg/kg. Neuromuscular block was studied using both single twitch and train-of-four (TOF) nerve stimulation. The onset time, duration of clinical action and TOF recovery of pipecuronium were measured. The o nset time of pipecuronium was significantly more rapid in patients rec eiving propofol compared with those administered thiopental (2.75 +/- 0.54 vs 3.85 +/- 1.08 minutes; p<0.001). The duration of clinical acti on was not statistically significant between the two drugs, while the TOF ratios were significantly higher in patients receiving propofol. P ropofol significantly reduces the onset time of pipecuronium and short ens its recovery when compared with thiopental.