Various chiral stationary phases (CSPs) consisting of polysaccharide d
erivatives were developed by adsorbing them on silica gel on the basis
of information obtained from cellulose triacetate. The chiral recogni
tion ability increases with an increase in conformational regularity.
The regularity of cellulose triacetate depends greatly on the kind of
solvents used in the coating procedure. This finding seems to be appli
cable to other coating-type CSPs based on polysaccharide derivatives.
Some interactions were considered between a CSP and an enantiomer for
chiral discrimination. By using C-13 NMR spectroscopy, 1-phenylethyl a
lcohol was chirally recognized on cellulose tris(4-methylbenzoate).