N. Oi et al., DIRECT ENANTIOMER SEPARATIONS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH CHIRAL UREA DERIVATIVES AS STATIONARY PHASES, Journal of chromatography, 694(1), 1995, pp. 129-134
The chromatographic properties of urea derivatives derived from (S)- a
nd (R)-1-(alpha-naphthyl)ethylamine with (S)-valine, (S)-tert.-leucine
, (S)-proline and (S)-indoline-2-carboxylic acid bonded to 3-aminoprop
ylsilica gel as chiral stationary phases were examined by HPLC to inve
stigate the effect of the structure of the amino acid moiety. The spec
ific enantiomer separation of various racemic compounds including alco
hols, esters, amines, amino alcohols, carboxylic acids and amino acids
was accomplished on these phases using normal mobile phases. The effe
ct of the stereochemical structure in these urea derivatives on chiral
recognition is discussed.