USING CHIRALITY AS A UNIQUE PROBE OF PHARMACOLOGICAL PROPERTIES

The development of enantioselective chromatographic techniques has mad e it feasible to routinely follow the metabolism and disposition of th e separate enantiomers of a chiral drug. These studies are a source of data about in vivo pharmacological processes. The key question is rec ognition of the fundamental information contained within the results a nd the application of this data to the development of a deeper underst anding of the clinical consequences of stereochemistry. This manuscrip t presents two examples of how chirality can be used as a unique probe of basic pharmacological properties.