USE OF CYCLODEXTRINS IN CAPILLARY ELECTROPHORESIS FOR THE CHIRAL RESOLUTION OF SOME 2-ARYLPROPIONIC ACID NONSTEROIDAL ANTIINFLAMMATORY DRUGS

The enantiomeric separation of racemic compounds of some 2-arylpropion ic acid non-steroidal anti-inflammatory drugs (profens), namely fenopr ofen, ibuprofen, flurbiprofen, suprofen, ketoprofen and indoprofen, wa s performed by capillary zone electrophoresis. The separation was obta ined by supporting the background electrolyte with derivatized beta-cy clodextrins. The type and concentration of cyclodextrin used and the b ackground electrolyte composition (pH and amount of methanol) influenc ed the complexation and the chiral resolution. All the modified beta-c yclodextrins used (heptakis-2,6-di-O-methyl-beta-, heptakis-2,3,6-tri- O-methyl- and 6(A)-methylamino-beta-cyclodextrin) showed good complexi ng effects with the profens tested. Tri-O-methyl-beta-cyclodextrin pro ved to be the best stereoselective additive because it allowed the ena ntiomeric resolution of all the profens studied whereas the dimethylat ed and methylamino-beta-cyclodextrin were able to separate only some o f them.