ABILITY OF NONCYCLIC OLIGOSACCHARIDES TO FORM MOLECULAR-COMPLEXES ANDITS USE FOR CHIRAL SEPARATION BY CAPILLARY ZONE ELECTROPHORESIS

The binding constants (K) for complexation of the phenyl acetates with linear alpha-1,4-linked dextrins have been determined from the kineti cs of the hydrolyses of the esters. The K value tends to increase with increasing the number of the glucopyranose units, suggesting hydropho bic interaction as a binding force. The weak ability of the linear dex trins to form the molecular complexes makes it possible to separate th e enantiomers of binaphthyl derivatives such as 1,1'-binaphthyl-2,2'-d icarboxylic acid, 1,1'-binaphthyl-2,2'-diyl hydrogenphosphate and 2,2' -dihydroxy-1,1'-binaphthyl-3,3'-dicarboxy acid in their anionic forms. Hydrogen bonding as well as hydrophobic interaction is suggested as a n essential force for enantioselective complexation between saccharide and anionic binaphthyl.