D1 RECEPTORS MODULATE STRIATAL DOPAMINE RELEASE INDUCED BY THE STIMULATION OF BOTH D1 AND D2 RECEPTORS - IN-VIVO VOLTAMMETRIC DATA REVISITED

Here we re-examine previous data that demonstrated lasting effects of the selective D1 receptor agonist SKF 38393, the selective D2 receptor agonist LY 171555, and of mixed SKF 39383 + LY 171555 upon striatal D A release. We demonstrate that the administration of mixed SKF 38393 LY 171555 and of SKF 38393 administered alone induced similar time-co urse effects upon striatal DA release that showed significant parallel developments. We discuss these data in the light of the current liter ature and we suggest that D1 receptors could play a modulating role on the striatal DA activity and the release of DA in the caudate-putamen .