AGREEMENT BETWEEN THE CLASSICAL UREA KINETIC-MODEL AND DIRECT DIALYSIS QUANTIFICATION - IMPORTANCE OF UREA REBOUND

From a review of the literature regarding kinetic models used for asse ssing the adequacy of hemodialysis, no definite conclusions can be dra wn as to whether the classical urea kinetic model (UKM) or modified di rect dialysis quantification (mDDQ) is more reliable. We compared mDDQ with classical UKM and with a modified UKM that employs an equilibrat ed urea value. From the theoretical viewpoint, no substantial conflict is found between the two models as regards the dialysis dose, if urea rebound is considered. From the practical viewpoint, in our opinion d irect quantification lends itself better for experimental purposes whe reas for routine K-t/V evaluation UKM is easier and accurate enough, p rovided that rebound is taken into account.