SYNTHESIS AND PHARMACOLOGICAL CHARACTERIZATION OF SOME BENZAZEPINONE DERIVATIVES

Citation
R. Budriesi et al., SYNTHESIS AND PHARMACOLOGICAL CHARACTERIZATION OF SOME BENZAZEPINONE DERIVATIVES, Arzneimittel-Forschung, 45-1(3), 1995, pp. 234-239
Citations number
17
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
ISSN journal
00044172
Volume
45-1
Issue
3
Year of publication
1995
Pages
234 - 239
Database
ISI
SICI code
0004-4172(1995)45-1:3<234:SAPCOS>2.0.ZU;2-1
Abstract
A series of some benzazepinone derivatives were prepared. The compound s were evaluated for inotropic, chronotropic and calcium antagonist pr operties. For the compounds bearing well-known alpha-blocking fragment s the antagonist potency at postsynaptic alpha-adrenoceptors was asses sed. The new compounds were less effective as bradycardic agents and c alcium antagonists but show remarkable negative inotropic activity.