R. Budriesi et al., SYNTHESIS AND PHARMACOLOGICAL CHARACTERIZATION OF SOME BENZAZEPINONE DERIVATIVES, Arzneimittel-Forschung, 45-1(3), 1995, pp. 234-239
A series of some benzazepinone derivatives were prepared. The compound
s were evaluated for inotropic, chronotropic and calcium antagonist pr
operties. For the compounds bearing well-known alpha-blocking fragment
s the antagonist potency at postsynaptic alpha-adrenoceptors was asses
sed. The new compounds were less effective as bradycardic agents and c
alcium antagonists but show remarkable negative inotropic activity.