SYNTHESIS AND PHARMACOLOGICAL CHARACTERIZATION OF SOME BENZAZEPINONE DERIVATIVES

A series of some benzazepinone derivatives were prepared. The compound s were evaluated for inotropic, chronotropic and calcium antagonist pr operties. For the compounds bearing well-known alpha-blocking fragment s the antagonist potency at postsynaptic alpha-adrenoceptors was asses sed. The new compounds were less effective as bradycardic agents and c alcium antagonists but show remarkable negative inotropic activity.