EVALUATION OF THE MUTAGENICITY OF MEDROXYPROGESTERONE ACETATE IN-VITRO AND IN-VIVO

Authors
HERZOG R LEUSCHNER J
Citation
R. Herzog et J. Leuschner, EVALUATION OF THE MUTAGENICITY OF MEDROXYPROGESTERONE ACETATE IN-VITRO AND IN-VIVO, Arzneimittel-Forschung, 45-1(3), 1995, pp. 311-314
Citations number
3
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Arzneimittel-Forschung → ACNP
ISSN journal
00044172
Volume
45-1
Issue
3
Year of publication
1995
Pages
311 - 314
Database
ISI
SICI code
0004-4172(1995)45-1:3<311:EOTMOM>2.0.ZU;2-2
Abstract
Medoxyprogesterone acetate (CAS 71-58-9) is used for cyclic hormone su bstitution during the menopause and in hormone therapy of breast cance r. The test substance was investigated for its mutagenic potential in a series of test systems according to the current EC guidelines. There were no indications for a mutagenic potential of medroxyprogesterone acetate.