LINGUAL HYPERPIGMENTATION ASSOCIATED WITH MINOCYCLINE THERAPY

Minocycline can cause hyperpigmentation of the conjunctiva, oral mucos a, and skin. Pigmentation of the oral mucosa may also be associated wi th a variety of endogenous or exogenous factors. Lingual pigmentation may be seen in Addison's disease, amalgam tatoo, malignant melanoma, P eutz-Jegher's syndrome, and other diseases. Two women who had isolated pigmentation of the tongue while taking minocycline are described; no other drug-induced pigmentation of their oral mucosa or skin occurred . Minocycline-induced pigmentation should be added to the differential diagnosis oi isolated lingual hyperpigmentation.