CARBONIC-ANHYDRASE - AN EXAMPLE OF HOW THE CAVITY GOVERNS THE REACTIVITY AT THE ZINC ION

Authors
BERTINI I LUCHINAT C MANGANI S PIERATTELLI R
Citation
I. Bertini et al., CARBONIC-ANHYDRASE - AN EXAMPLE OF HOW THE CAVITY GOVERNS THE REACTIVITY AT THE ZINC ION, Comments on modern chemistry. Part A, Comments on inorganic chemistry, 17(1), 1995, pp. 1-15
Citations number
39
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Comments on modern chemistry. Part A, Comments on inorganic chemistry → ACNP
ISSN journal
02603594
Volume
17
Issue
1
Year of publication
1995
Part
A
Pages
1 - 15
Database
ISI
SICI code
0260-3594(1995)17:1<1:C-AEOH>2.0.ZU;2-U
Abstract
The recent availability of X-ray structures and new biophysical measur ements have shed further light on the detailed mechanism of carbonic a nhydrase and its inhibition. It is noted that in some instances the st ructural information obtained through X-ray analysis of single crystal s and NMR measurements in solution disagree. We take these conflicting results as possible conformations close in energies, both of which ca n be used to design the enzymatic pathway.