EFFICACY AND TOLERANCE OF DICLOFENAC SODIUM 0.1-PERCENT, FLURBIPROFEN0.03-PERCENT, AND INDOMETHACIN 1.0-PERCENT IN CONTROLLING POSTOPERATIVE INFLAMMATION
M. Diestelhorst et al., EFFICACY AND TOLERANCE OF DICLOFENAC SODIUM 0.1-PERCENT, FLURBIPROFEN0.03-PERCENT, AND INDOMETHACIN 1.0-PERCENT IN CONTROLLING POSTOPERATIVE INFLAMMATION, Journal of cataract and refractive surgery, 22, 1996, pp. 788-793
Purpose: To compare the anti-inflammatory effect of diclofenac sodium
0.1% ophthalmic solution, flurbiprofen 0.03% ophthalmic solution, and
indomethacin 1.0%. Setting: Department of Ophthalmology, University of
Koln, and Bundesknappschaftskrankenhaus, Sulzbach, Germany. Methods:
One hundred seventeen patients enrolled in this prospective, randomize
d, double-masked, and parallel-group study had phacoemulsification and
intraocular lens implantation and received one of the three solutions
. Preoperatively at day 1 and postoperatively at day 4 or 5 and day 12
, 13, or 14, they were examined by slitlamp, applanation tonometry, an
d laser flare meter. Results: Anterior chamber flare reduction from ba
seline was significantly greater in the diclofenac group than in the f
lurbiprofen group (P = .022). Patients in the diclofenac group had sig
nificantly less burning and stinging than those in the flurbiprofen an
d indomethacin groups at postoperative days 4-5 and 12-14 (P = .001).
Conclusion: Diclofenac sodium appeared to be more potent than flurbipr
ofen in controlling intraocular inflammation after cataract surgery an
d appeared to be locally tolerated better than flurbiprofen and indome
thacin.