ANNEXIN V-COATED INTRAOCULAR LENSES

Purpose: To assess whether annexin V-coated poly(methyl methacrylate) (PMMA) intraocular lenses (IOLs) prevent postoperative inflammation in rabbit eyes. Setting: Department of Ophthalmology, Hopital Purpan, To ulouse, France. Methods: Thirteen IOLs coated with annexin V were impl anted in 13 rabbit eyes; the contralateral eyes received uncoated IOLs . Postoperative fibrin was quantitated by daily slitlamp examination u ntil the anterior chamber was completely clear. Results were analyzed using a Wilcoxon test. Ocular toxicity was evaluated by light and elec tron microscopy. Results: Eyes with the annexin V-coated IOLs had less severe inflammation on the first postoperative day, and the inflammat ion resolved more quickly than in eyes with uncoated IOLs (P < .05). N o annexin V was released postoperatively, nor were there signs of ocul ar toxicity. Conclusion: Annexin V-coated lenses effectively reduced p ostoperative inflammation in rabbit eyes.