OPTICALLY-ACTIVE N-1-PHENYLETHYL DERIVATIVES OF (1R)-2-AMINO-1-PHENYLETHANOL AS CHIRAL AUXILIARIES IN THE ENANTIOSELECTIVE ADDITION OF DIETHYLZINC TO ARYLALDEHYDES

Authors
IULIANO A PINI D SALVADORI P
Citation
A. Iuliano et al., OPTICALLY-ACTIVE N-1-PHENYLETHYL DERIVATIVES OF (1R)-2-AMINO-1-PHENYLETHANOL AS CHIRAL AUXILIARIES IN THE ENANTIOSELECTIVE ADDITION OF DIETHYLZINC TO ARYLALDEHYDES, Tetrahedron : asymmetry, 6(3), 1995, pp. 739-744
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
6
Issue
3
Year of publication
1995
Pages
739 - 744
Database
ISI
SICI code
0957-4166(1995)6:3<739:ONDO(>2.0.ZU;2-H
Abstract
The aminoalcohols (1R)-2-N[(R)-1-phenylethyl]amino-1-phenylethanol, (1 R)-2-N[(S)-1- phenylethyl]amino-1-phenylethanol, and (1R)-2-N-methyl-N [(R)-1-phenylethyl]amino synthesized by simple procedures, have been u sed as chiral catalysts in the enantioselective addition of diethylzin c to arylaldehydes, obtaining optically active 1-arylpropanols in good chemical yields (47 to 95%) and e.e.s up to 88%.