SYNTHESIS OF NEW ALKYLAMINOALKYL THIOSEMICARBAZONES OF 3-ACETYLINDOLEAND THEIR EFFECT ON DNA-SYNTHESIS AND CELL-PROLIFERATION

Authors
SIATRAPAPASTAIKOUDI T TSOTINIS A RAPTOPOULOU CP SAMBANI C THOMOU H
Citation
T. Siatrapapastaikoudi et al., SYNTHESIS OF NEW ALKYLAMINOALKYL THIOSEMICARBAZONES OF 3-ACETYLINDOLEAND THEIR EFFECT ON DNA-SYNTHESIS AND CELL-PROLIFERATION, European journal of medicinal chemistry, 30(2), 1995, pp. 107-114
Citations number
23
Categorie Soggetti
Chemistry Medicinal
Journal title
European journal of medicinal chemistry → ACNP
ISSN journal
02235234
Volume
30
Issue
2
Year of publication
1995
Pages
107 - 114
Database
ISI
SICI code
0223-5234(1995)30:2<107:SONATO>2.0.ZU;2-Q
Abstract
The preparation of a number of thiosemicarbazones of 3-acetylindole is described. These compounds were evaluated in vitro for their effect o n proliferation and cell-division delays in cultured human peripheral blood lymphocytes, and their effect on DNA synthesis in T-cell leukemi a Molt-4 cells.