RESEARCH ON ANTIBACTERIAL AND ANTIFUNGAL AGENTS .11. SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF N-HETEROARYL BENZYLAMINES AND THEIR SCHIFF-BASES

Authors
FIORAVANTI R BIAVA M PORRETTA GC LANDOLFI C SIMONETTI N VILLA A CONTE E PORTAPUGLIA A
Citation
R. Fioravanti et al., RESEARCH ON ANTIBACTERIAL AND ANTIFUNGAL AGENTS .11. SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF N-HETEROARYL BENZYLAMINES AND THEIR SCHIFF-BASES, European journal of medicinal chemistry, 30(2), 1995, pp. 123-132
Citations number
16
Categorie Soggetti
Chemistry Medicinal
Journal title
European journal of medicinal chemistry → ACNP
ISSN journal
02235234
Volume
30
Issue
2
Year of publication
1995
Pages
123 - 132
Database
ISI
SICI code
0223-5234(1995)30:2<123:ROAAAA>2.0.ZU;2-P
Abstract
The synthesis and antimicrobial activity of new N-heteroaryl benzylami nes and their Schiff bases are reported. Antifungal data were compared with those obtained with miconazole ketoconazole, enilconazole and im azalil sulfate; which showed that some of the tested compounds possess ed moderate activity against strains of Candida albicans, Candida sp a nd good activity against isolates of plant pathogenic fungi, In contra st the synthesized compounds showed poor antibacterial activity, excep t for 3j which exhibited a better activity than nalidixic acid used as positive control. The results obtained are discussed on the basis of structure-activity relationships.