F. Djedainipilard et al., POTENTIAL FORMATION OF INTRAMOLECULAR INCLUSION COMPLEXES IN PEPTIDO-CYCLODEXTRINS AS EVIDENCED BY NMR-SPECTROSCOPY, Perkin transactions. 2, (4), 1995, pp. 723-730
Investigations of the structure of beta- and gamma-cyclodextrin dagger
derivatives in solution obtained by grafting amino acids or peptides
are presented. These compounds are models for vectorization-dedicated
molecular carriers. It is shown that for some amino acids, strong intr
amolecular self-inclusion complexes are formed in aqueous solution. Th
is process strongly depends upon the nature and position of the pertin
ent amino acid in the peptide sequence. Two dimensional NMR experiment
s are used in conjunction with competition with external guests to evi
dence and estimate the strength of these auto-inclusion complexes.