EFFECTS OF MACROMOLECULAR ADHESION FACTOR S ON PROLIFERATION OF THE HEPATOCYTES IN THE ORGAN-CULTURES OF THE EMBRYONIC MOUSE-LIVER

The use of macromolecular adhesion factors (MAF) as a molecular tool m ade it possible to establish that at least two molecular mechanisms of cell adhesion are violated in the livers of mice genetically predispo sed to spontaneous hepatoblastomogenesis in the late embryonic stages and during the early postnatal period. The biological effect of MAF on the adhesion properties of embryonic hepatocytes correlated with thei r influence on cell proliferation. It has been proposed that violation of the molecular mechanisms of cell adhesion is the key moment in spo ntaneous blastomogenesis.