ON THE MECHANISM OF ACTION OF 1,3,2-OXAZA PHOSPHIRINAN DERIVATIVES ONINSECTS

The insecticide effect and combined action of two groups of 1,3,2-oxaz aphosphorinan derivatives together with pyrethroids on house flies and synanthropic cockroaches were studied. The mechanisms underlying the action of these compounds involving interaction with the esterase comp lex, monooxygenase systems, and glutathione-S-transferase of insects h ave also been investigated. The compounds studied do not exert the ins ecticide effect, but enhance the effects of permetrin and sumitrin on the insects. The synergistic effect depends on the length of the carbo n chain in the alctiol substitute of 2-alkylmercapto-2-tio-1,3,2-oxaza phosphorinan. This effect correlates with the anticarboxylesterase act ivity found by PAAG. A possible scheme of metabolism of 1,3,2-oxazapho sphorinan has been proposed, according to which metabolites with a hig h antiesterase activity can be formed in insects.