UV SPECTROSCOPIC STUDY AND CONFORMATIONAL-ANALYSIS OF DOMPERIDONE

The UV absorption spectra of domperidone, 2-(3H)-benzimidazolone and 5 -Cl-2-(3H)-benzimidazolone in CH3CN have been studied both in the abse nce and in the presence of hard acids. A theoretical analysis of the e lectronic transitions of 2-(3H)-benzimidazolone has also been performe d by means of quantum-mechanical methods. Molecular mechanics (force f ield) calculations have been carried out to characterize the conformat ional space of domperidone. The results show a large number of conform ers lying with 3 kcal mol(-1) with respect to the lowest energy struct ure.