A NEW METHOD FOR THE RESOLUTION OF AMINES AND ITS APPLICATION TO 3-AMINO-1,5-BENZODIAZEPINES

Authors
CUROTTO G DONATI D FINIZIA G URSINI A
Citation
G. Curotto et al., A NEW METHOD FOR THE RESOLUTION OF AMINES AND ITS APPLICATION TO 3-AMINO-1,5-BENZODIAZEPINES, Tetrahedron : asymmetry, 6(4), 1995, pp. 849-852
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
6
Issue
4
Year of publication
1995
Pages
849 - 852
Database
ISI
SICI code
0957-4166(1995)6:4<849:ANMFTR>2.0.ZU;2-#
Abstract
A new method for the resolution of racemic amines and its application to 3-amino-1,5-benzodiazepines is reported. The method is based upon t he reaction of the amines with a chiral auxiliary, namely the tosyl de rivative of (S)-(+)-methyl mandelate, followed by the separation of th e two diastereomers formed and the subsequent hydrogenation of the sep arated compounds to give the free chiral amines with good enantiomeric excesses.