H. Mineo et al., EFFECTS OF INTRAVENOUS INFUSIONS OF CHOLECYSTOKININ (CCK)-8 ON EXOCRINE AND ENDOCRINE PANCREATIC-SECRETION IN CONSCIOUS SHEEP, Comparative biochemistry and physiology. Part A, Physiology, 111(1), 1995, pp. 133-138
The effects of cholecystokinin (CCK)-8 on both exocrine and endocrine
pancreatic functions were examined simultaneously in five conscious sh
eep. Intravenous infusions of CCK-8 (0, 5, 10, 20, 30, 60, 120 and 240
pmol/kg/min for 40 min) induced dose-dependent increases in flow rate
, and in protein and amylase outputs in pancreatic juice. The same CCK
-8 infusions induced dose-dependent increases in plasma insulin, but n
o change in plasma glucagon concentrations. The threshold dose (10-30
pmol/kg/min) of CCK-8 infusion for stimulating insulin secretion was s
imilar to that for stimulating amylase output. In conclusion, using am
ylase output as an indicator of physiological action, CCK is one of th
e potential candidates as a physiological regulator of insulin, but no
t glucagon secretion in sheep.