M. Kalder et al., FETAL DEVELOPMENT IN MILD AND SEVERE PRAEECLAMPSIA - CORRELATION TO MATERNAL LABORATORY VALUES AND BLOOD-FLOW VELOCIMETRY, Zeitschrift fur Geburtshilfe und Perinatologie, 199(1), 1995, pp. 13-17
During three and a half years we observed 83 single pregnancies all de
livered by caesarean section. All of them had a mild (systolic blood p
ressure >140, diastolic >90 and proteinuria >0,5 g/dl) or a severe pre
eclampsia (systolic blood pressure >160, diastolic >100 and proteinuri
a >3,0 g/dl). We found significantly twice as many abnormal uteroplace
ntal blood flow velocities in the severe preeclampsia group than in th
e mild one. These results draw us to the conclusion that possible path
ological changing of the vessels is due to preeclampsia which does not
need to correlate with a placental insufficiency and fetal growth ret
ardation. An abnormal uteroplacental blood flow velocity connected wit
h an abnormal umbilical blood flow velocity raises the fetal morbidity
and the early childhood morbidity. Fetal outcome in mild compared to
severe preeclampsia definitively shows a worse prognosis for those fet
uses whose mother developed a prepartal severe preeclampsia. A distinc
tly increased rate of cerebral haemorrhages, abnormal neurological sig
ns, acute respiratory distress syndroms and bronchopulmonary dysplasia
was found. Finally we show an additional risk for fetal outcome in ab
sent or reverse enddiastolic flow velocity (AREDFV) in the severe pree
clampsia group. We observed in the AREDFV group with severe preeclamps
ia in comparison to a group of AREDFV without maternal preeclampsia mo
re than twice as many cerebral haemorrhages, abnormal neurological sig
ns and bronchopulmonary dysplasia.