A COMPARATIVE CEREBRAL BLOOD-FLOW STUDY IN A BABOON MODEL WITH ACETAZOLAMIDE PROVOCATION - TC-99M-HMPAO VS I-123(IMP)

Pharmacological interactions are important when nuclear medical proced ures are applied to patients under drug therapy, or drug provocation. This study compares in baboon models (regional) cerebral blood flow [( r)CBF] results from (99m)TcHMPAO and I-123-iodoamphetamine [I-123(IMP) ] each with and without acetazolamide, the latter a suggested drug for testing cerebrovascular reserve. Expected differences in cerebral upt ake were observed between the two radio-tracers without acetazolamide. The increase in tracer uptake resulting from acetazolamide is signifi cantly enhanced for I-123(IMP), which could have diagnostic implicatio ns.