Bf. Spielvogel, BORON ANALOGS OF BIOMOLECULES - BIOMEDICAL PROSPECTS, Phosphorus, sulfur and silicon and the related elements, 87(1-4), 1994, pp. 267-276
Boron analogues of a variety of biologically important molecules have
been synthesized and characterized. Analogues of amino acids, peptides
, phosphonates, nucleosides, nucleic acids, and other derivatives, all
containing 4-coordinate boron, possess sufficient hydrolytic and oxid
ative stability to be useful under physiological conditions. Bearing c
lose structural resemblance to their natural organic counterparts (but
different charge), the boron analogues exhibit potent biological acti
vity and possess a wide variety of pharmacological behavior such as hy
polipidemic, anticancer, anti-inflammatory, anti-osteoporosis, and oth
er activity in animal model studies. Boron analogues may also be usefu
l in boron neutron capture therapy for the treatment of cancer. Other
applications to medical diagnostics exist.