THE SYNTHESIS OF NOVEL DERIVATIVES OF DRO-4-MERCAPTO-2,6-DIOXO-1,3,5,2-TRIAZAPHOSPHORINE AND THEIR ANTITUMOR-ACTIVITY

Authors
CHEN RY MAO LJ CHEN XR
Citation
Ry. Chen et al., THE SYNTHESIS OF NOVEL DERIVATIVES OF DRO-4-MERCAPTO-2,6-DIOXO-1,3,5,2-TRIAZAPHOSPHORINE AND THEIR ANTITUMOR-ACTIVITY, Phosphorus, sulfur and silicon and the related elements, 89(1-4), 1994, pp. 83-88
Citations number
6
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Phosphorus, sulfur and silicon and the related elements → ACNP
ISSN journal
10426507
Volume
89
Issue
1-4
Year of publication
1994
Pages
83 - 88
Database
ISI
SICI code
1042-6507(1994)89:1-4<83:TSONDO>2.0.ZU;2-X
Abstract
A series of new derivatives of dro-4-mercapto-2,6-dioxo-1,3,5,2-triaza phosphorine have been synthesized. The most stable tautomer was proven to have the thioenol form by spectroscopic data and quantum chemistry calculation. The preliminary bioassay indicated that the title compou nds significantly inhibited the growth of jurkat cells in vitro as wel l as S-180 tumor in vivo.