SYNTHESIS AND PROPERTIES OF NOVEL NITROGEN-MUSTARD LINKED PHOSPHORYL DIAMIDE DERIVATIVES

Authors
CHEN RY MAO LJ WANG HL ZHOU J
Citation
Ry. Chen et al., SYNTHESIS AND PROPERTIES OF NOVEL NITROGEN-MUSTARD LINKED PHOSPHORYL DIAMIDE DERIVATIVES, Phosphorus, sulfur and silicon and the related elements, 89(1-4), 1994, pp. 89-95
Citations number
6
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Phosphorus, sulfur and silicon and the related elements → ACNP
ISSN journal
10426507
Volume
89
Issue
1-4
Year of publication
1994
Pages
89 - 95
Database
ISI
SICI code
1042-6507(1994)89:1-4<89:SAPONN>2.0.ZU;2-Y
Abstract
Two series of novel phosphoryl diamide derivatives (3, 4), containing the nitrogen mustard group were synthesized, and the effects of substi tuents on the reactivity and the spectral properties are discussed. Al l the compounds prepared were confirmed by H-1 NMR, IR, MS, P-31 NMR a nd elemental analysis. Preliminary bioassays indicate that compounds 3 have good antitumor activities, and some of compounds 4 display high inhibitory activities against the tobacco mosaic virus (TMV).