SOME ARYL SEMICARBAZONES POSSESSING ANTICONVULSANT ACTIVITIES

A number of aryl semicarbazones displayed anticonvulsant activity in t he maximal electroshock (MES) and subcutaneous pentylenetetrazole (scP TZ) screens when administered intraperitoneally to mice. When given by the oral route to rats, protection was afforded in the MES but not sc PTZ tests. Correlations were noted between the sigma and sigma values of the aryl substituents, the interplanar angles made by the aryl rin gs with the adjacent carbimino groups and the shapes of certain semica rbazones determined by X-ray crystallography, and the activities in th e rat oral MES screen. Molecular modeling studies revealed a number of statistically significant descriptors which contributed to anticonvul sant activity.